Guyana’s Foreign Secretary Robert Persaud said the six people arrived on Saturday after being vetted and found to have no criminal backgrounds.
“The US has not made any further requests” for non-citizen deportations to be sent to Guyana at this time, Persaud told The Associated Press news agency.
Persaud said Guyana agreed to receive the deportees after months of negotiations.
The one-year arrangement does not constitute permanent resettlement, he said.
The latest deportations are part of the Trump administration’s broader campaign to remove migrants from the United States, including through arrangements that send foreign nationals to countries other than their countries of origin.
More than 30 countries have entered such agreements with the United States since Trump returned to office, according to Amnesty International, including 15 countries in the Americas.
Third-country deportations can send people to countries they have never lived in, where they may have no familiarity with local conditions or language.
The Trump administration has expanded such arrangements with governments around the world, including several in Africa, with some agreements involving multimillion-dollar payments.
US officials have defended the policy by arguing that countries such as Cuba refuse to accept deportees from the United States.
Rights groups, however, have condemned the practice as a means of punishing migrants and pressuring them to abandon their immigration claims in the United States.
Many people subjected to the deportations have no criminal background.
The Transactional Records Access Clearinghouse (TRAC), a research organisation at Syracuse University, estimates that 70.6 percent of foreign nationals currently in US immigration detention have no criminal conviction.
The policy has also raised concerns over the conditions awaiting deportees in countries facing poverty, instability, conflict or human rights abuses.
The six people sent to Guyana will receive assistance through the Assisted Voluntary Return Programme, run by the United Nations International Organisation for Migration (IOM).
Under the arrangement, they will remain in Guyana while their immigration cases are determined.
They could eventually return to their countries of origin or seek relocation elsewhere.
The Trump administration has also cancelled immigration protections, including programmes such as Temporary Protected Status and humanitarian parole, leaving tens of thousands of migrants exposed to deportation.
Reports have also emerged that the administration plans to strip visas from roughly 200,000 people seeking asylum.
The removal of legal immigration status can expose migrants to deportation even when conflicts or unstable conditions remain in their countries of origin.