All eight Round of 16 ties promise to be thrillers with all the hopefuls aiming to lift the coveted trophy for the first time.
Group C runner-up Sepahan will have to face Qatar's Al Ahli, the Group B winner. Al Ahli topped its group with 10 points - registering two wins and four draws - while Sepahan had two wins, a draw and a defeat.
Also, Esteghlal will face Group C winner Al Hussein of Jordan.
Al Hussein registered three wins against one defeat in the group stage while Esteghlal only won twice.
The Round of 16 is scheduled to be played in February 2026 (West: 10-11, 17-18; East: 11-12, 18-19), followed by the Quarter-finals in March (West: 3-4, 10-11; East: 4-5, 11-12) and Semi-finals in April (West: 7 and 14; East: 8 and 15).
The tournament will culminate in a single-leg West-meets-East Final on May 16, 2026.
Round of 16
West
Al Zawraa SC (IRQ) v Al Wasl FC (UAE)
FC Arkadag (TKM) v Al Nassr Club (KSA)
Sepahan SC (IRN) v Al Ahli SC (QAT)
Esteghlal FC (IRN) v Al Hussein (JOR)
East
FC Pohang Steelers (KOR) v Gamba Osaka (JPN)
Ratchaburi FC (THA) v Persib Bandung (IDN)
Bangkok United (THA) v Macarthur FC (AUS)
Cong An Ha Noi FC (VIE) v Tampines Rovers FC (SGP)