Soroush Rafiei’s right-footed strike in the 24th minute sealed the victory for the Reds.
Mes was reduced to 10-man in the 70th minute after its defender Amir Hossein Sedghi recieved his second yellow card.
Also, Tractor was held to a goalless draw by Shams Azar in Qazvin. Malavan defeated Aluminum 1-0 in Arak and Foolad edged past Fajr Sepasi 2-1 in Shiraz.
On Saturday, Paykan will meet Kheybar in Tehran and Sepahan host Chadormalou in Isfahan.
Persepolis leads the table with 28 points, while relegation-threatened Mes remained bottom of the table with eight points.